TABLE 3.
Diagnostic performances of B-US-RS, SWE-RS, quantitative SWE parameters, and BI-RADS assessment in the training cohort.
| Parameter | Threshold | Sensitivity (%)* | Specificity (%)* | AUC* | Positive likelihood ratio | Negative likelihood ratio |
| B-US-RS | −1.28 | 100 (92–100) [58/58] | 99 (96–100) [139/140] | 0.99 (0.99–1.00) | 140 (19.86–986.92) | 0 (0–0) |
| SWE-RS | −0.24 | 98 (99–100) [57/58] | 100 (97–100) [140/140] | 0.99 (0.99–1.00) | ∞ | 0.02 (0.0025–0.12) |
| Quantitative SWE parameter | ||||||
| Emax (kPa) | >46.45 | 83 (70–91) [48/58] | 88 (81–93) [123/140] | 0.92 (0.88–0.96) | 6.82 (4.30–10.80) | 0.20 (0.11–0.34) |
| Emean (kPa) | >35.35 | 83 (70–91) [48/58] | 91 (85–95) [128/140] | 0.91 (0.86–0.96) | 9.66 (5.55–16.80) | 0.19 (0.11–0.33) |
| Eratio (kPa) | >4.15 | 76 (63–86) [44/58] | 89 (82–93) [124/140] | 0.86 (0.79–0.92) | 6.64 (4.09–10.8) | 0.27 (0.17–0.43) |
| ESD (kPa) | >10.35 | 76 (63–86) [44/58] | 94 (88–97) [131/140] | 0.92 (0.88–0.96) | 11.8 (6.17–22.57) | 0.26 (0.16–0.41) |
| Combined quantitative SWE parameters | −0.87 | 83 (70–91) [48/58] | 93 (87–96) [130/140] | 0.92 (0.88–0.97) | 11.59 (6.30–21.30) | 0.18 (0.10–0.33) |
| BI-RADS category at US | >3 | 95 (85–99) [55/58] | 54 (46–63) [76/140] | 0.94 (0.89–0.98) | 2.07 (1.71–2.51) | 0.09 (0.03–0.29) |
Data in parentheses are 95% confidence intervals and data in brackets are raw data. US, ultrasonography; RS, radiomics signature; SWE, shear-wave elastography; BI-RADS, Breast Imaging Reporting and Data System; and AUC, area under the curve. * P values for statistical significance are corrected to 0.008 for multiple testing using Bonferroni correction.