TABLE 4.

Diagnostic performances of B-US-RS, SWE-RS, quantitative SWE parameters, and BI-RADS assessment in the independent validation cohort.

Parameter	Threshold	Sensitivity (%)*	Specificity (%)*	AUC*	Positive likelihood ratio	Negative likelihood ratio
B-US-RS	−1.28	100 (79–100) [19/19]	100 (90–100) [46/46]	1.00 (1.00–1.00)	∞	0
SWE-RS	−0.24	100 (79–100) [19/19]	100 (90–100) [46/46]	1.00 (1.00–1.00)	∞	0
Quantitative SWE parameter
Emax (kPa)	>46.45	84 (60–96) [16/19]	89 (76–96) [41/46]	0.93 (0.85–1.00)	7.75 (3.31–18.1)	0.18 (0.06–0.50)
Emean (kPa)	>35.35	84 (60–96) [16/19]	96 (84–99) [44/46]	0.91 (0.80–1.00)	19.37 (4.92–76.17)	0.16 (0.06–0.47)
Eratio (kPa)	>4.15	89 (66–98) [17/19]	87 (73–95) [40/46]	0.90 (0.80–1.00)	6.86 (3.20–14.70)	0.12 (0.03–0.45)
ESD (kPa)	>10.35	90 (66–98) [17/19]	96 (84–99) [44/46]	0.95 (0.89–1.00)	20.58 (5.26–80.52)	0.11 (0.03–0.41)
Combined quantitative SWE parameters	−0.87	84 (60–96) [16/19]	96 (84–99) [44/46]	0.94 (0.88–1.00)	19.37 (4.92–76.17)	0.16 (0.06–0.47)
BI-RADS category at US	>3	100 (79–100) [19/19]	54 (39–69) [25/46]	0.99 (0.97–1.00)	2.19 (1.59–3.00)	0 (0–0)

Data in parentheses are 95% confidence intervals and data in brackets are raw data. US, ultrasonography; RS, radiomics signature; SWE, shear-wave elastography; BI-RADS, Breast Imaging Reporting and Data System; and AUC, area under the curve. * P values for statistical significance are corrected to 0.008 for multiple testing using Bonferroni correction.