Figure 7.

Validation of the model by curative intravesical treatment of clinically relevant compounds. Rats were treated with either DMSO (50%, i.ves.), Ialuril^® (i.ves.) or saline vehicle (500 µl/rat, i.ves.) on day 7. (A) Nociceptive response was assessed at day 7, once the cystitis was established but before start of the pharmacological treatment (Before) and at day 10 (Post). Nociceptive score was expressed as the percentage of the maximal score for each von Frey force. (B) Bladder inflammation was assessed at day 10 by measuring bladder weight, wall thickness and edema scores. Data represent mean values ± SEM (n = 10 for Vehicle and Ialuril^® and n = 9 for DMSO). ^nsp > 0.05, *p < 0.05 (A) two-way RM ANOVA; (B) Mann Whitney or unpaired t test).