Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 28;11:1335. doi: 10.3389/fphar.2020.01335

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Lv, Zhang, Zhou, Feng, Yang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

I.T. injection of apelin alleviated the inﬂammatory pain induced by intradermal injection of CFA in mice. Normal saline (NS) was used as a control. The upward and downward arrows indicate the time points when i.d. and i.t. injection were administered. (A, B) Effect of apelin-13 (0.1, 1 and 10 nmol/mouse, i.t.) on PWL in response to thermal stimulation and PWT in response to Von Frey ﬁlament stimulation. (C) The effect of i.t. application of 10 nmol apelin-13, (pyr)apelin-13 and apelin-36 on PWL. (D) Effect of APJ receptor antagonist apelin-13(F13A) (20 nmol/mouse) on antinociception of (pyr)apelin-13 (10 nmol/mouse). Data are expressed as means ± SEM. n = 6–10 per group. *p < 0.05, compared with vehicle control (i.d. NS + i.t. NS); ^#p < 0.05, compared with CFA group (i.d. CFA + i.t. NS); ^§p < 0.05, compared with apelin-13-treated group (i.d. CFA + i.t. apelin-13). F13A, apelin-13(F13A).