Table 1.
Responses to treatment according to transcript types in pre-TKIs era.
| Reference | Total number of patients | E13a2 % | E14a2 % | E13a2+e14a2 % | Treatment | Comment |
|---|---|---|---|---|---|---|
| Lee et al. (68) | 134 | 38 | 52 | 10 | Interferon-α | MCyR1: 55% vs 24% in e13a2 and e14a2, respectively; p<0.0001. |
| Prejzner-Rego et al. (21) | 62 | 29.5 | 62.3 | 8.2 | Interferon-α | No significant differences in terms of response. |
| Shepherd et al. (20) | 219 | 40 | 55 | 5 | Interferon-α | No significant differences in terms of response and outcome. |
| Italian co-operative study group (22) | 146 | 43 | 57 | 0 | Interferon-α | E14a2: trend for higher MCyR1 and 5-year OS (p=ns2). |
| Mondal et al. (67) | 122 | 27 | 56.5 | 5 | Hdroxyurea, interferon-α | E13a2: trend for younger age, and higher WBC (p = ns2). |
MCyR: major molecular response; Ns= not significant.