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. 2020 Aug 28;11:547913. doi: 10.3389/fphar.2020.547913

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Copyright © 2020 Linghu, Xiong, Zhao, Zhang, Xiong, Zhao, Shen, Xu, Bian, Wang and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of SOE on animal growth and clinical score of arthritis index. The 36 Wistar male rats were randomly divided into 6 groups according to body weight as following: Ctrl (Vehicle), CIA (collagen-induced arthritis), CIA- SOE (SO extract, 0.16, 0.78, and 1.56 g/kg) and CIA-IND (indomethacin, 2.5 mg/kg). After the CIA was reproduced, drugs were administered intragastrically daily for five weeks. The body weight was recorded every week. Clinical arthritis scores were evaluated once a week. (A) The growth curve of rats (n = 6); (B) The severity of arthritis by the arthritis score (^##P < 0.01 vs. Ctrl group; ^*P < 0.05 and ^**P < 0.01 vs. CIA group, n = 6).