Table 1.
Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | Case 9 | Case 10 | Case 11 | |
---|---|---|---|---|---|---|---|---|---|---|---|
age | 36 years | 29 years | 60 years | 56 years | 58 years | 27 years | 21 years | 17 years | 35 years | 49 years | 58 years |
Sex | Male | Male | Male | Female | Male | Male | Male | Female | Male | Female | Female |
Hematological disease | B-cell ALL | B-cell ALLIsolated CNS Relapsed | Multiple myeloma | Multiple myeloma | Multiple myeloma | cHL | CML with T cell lymphoid blast crisis | B cell ALL | AML | AML | DLBCL |
Stem cell Transplant type | Allo HCT | Allo HCT | Auto /Allo HCT | Auto HCT | Auto HCT | Auto HCT | Allo HCT | Allo HCT | Allo HCT | Allo HCT | Auto HCT |
Time from HCT to COVID-19 symptoms | 10.7 month (+323days) | 5.6 month (+170 day) | 192 month | 71 month | 53 month | 9.1 month(+275days) | day +5 | 13.8month (+415 days) | 14 month (421 days) | 6.8 month (+206 days) | 2 month (+60 days) |
Prophylactic antimicrobials | Acyclovir, Bactrim | Acyclovir, Bactrim | Acyclovir, Bactrim | Acyclovir, Bactrim | Acyclovir, Bactrim | Acyclovir, Bactrim | Acyclovir | Acyclovir | Acyclovir posaconazole | Acyclovirbactrim | Acyclovir Bactrim fluconazole |
Immunosuppressant | non | tacrolimus | Dexamethasone | non | Dexamethasone Revlimid | Brentuximab | CSA,MMF | Dasatinib | predinosolone 15mg | non | non |
Disease status | remission | Relapsed | Relapsed | remission | remission | remission | Unknown | remission | remission | remission | remission |
COVID-19 Symptoms | fever and fatigue | fever, runny nose, headache and cough | Fever, headache, fatigue and body aches | headache, fatigability and SOB | Sore throat, fever and runny nose | Loss of smell | asymptomatic | asymptomatic | generalized fatigue, fever and productive cough | Cough, SOBSore throat andChest pain | Fever, SOB |
comorbidity | no | aGVHD skin | GVHD gut | DM,HTN,AF | morbid obesity, Hypothyroidism | no | no | no | DM | no | DM,HTN,CKD Hypothyroidism |
COVID-19 stage | mild | moderate | mild | moderate | mild | mild | moderate | mild | moderate | moderate | moderate |
Hospital admission | no | yes | yes | yes | no | no | no | no | yes | yes | yes |
Mechanical ventilation required | no | no | no | no | no | no | no | no | no | no | no |
COVID-19 treatment | Symptomatic treatment | Azithromycin, HCQ,Ceftriaxone | non | Ceftriaxone | symptomatic management | non | Azithromycin, HCQ meropenum | non | Azithromycin, HCQ, Ceftriaxone | symptomatic management | Azithromycin, HCQ meropenum |
Oxygen therapy required | no | no | no | no | no | no | no | no | no | no | no |
Chest X ary finding | Not indicated | ground-glass opacity in the left lower lung zone | Not indicated | opacity in right lower zone | Not indicated | Not indicated | multifocal patchy ground-glass opacities in left lung | Not indicated | bilateral patchy ground glass opacities | Not indicated | left lower lobe ground-glass opacities |
WBCs (3.9–11.0) 10^9/L | NA | 4.04 | NA | 2.86 | NA | NA | 0.07 | 6.8 | 4.69 | NA | 3.2 |
lymphocyte (1.5–4.3) 10^9/L | NA | 2.47 | NA | 0.8 | NA | NA | NA | 3.1 | 1.25 | NA | 1.85 |
Neutrophils(30.0–70.0) 10^9/L | NA | 1.36 | NA | 2.1 | NA | NA | NA | 3.0 | 2.4 | NA | 2./3 |
COVID-19 PCR follow up | negative70 days after confirming the infection | negative 33 days after confirming the infection | negative 86 days after confirming the infection | negative 81 days after confirming the infection | negative 91 days after confirming the infection | not done | positive 42 days after confirming the infection | negative 34 days after confirming the infection | negative 48 days after confirming the infection | not done | negative 65 days after confirming the infection |
SARS-Cov2 Total Antibody Screening | Reactiv 70 days after confirming the infection | Reactiv 33 days after confirming the infection | Reactive 86 days after confirming the infection | Reactiv 81 days after confirming the infection | Reactiv 91 days after confirming the infection | not done | Non Reactive 42 days after confirming the infection | not done | Non Reactive 48 days after confirming the infection | not done | Not done |
DM-diabetes mellitus, HTN-hypertension, CSA-cyclosporine, ALL-acute lymphoblastic leukemia, auto-autologous, HCT-hematopoietic cell transplant, AF-atrial-fibrillation, MM-Multiple myeloma, SOB-shortness of breath, GVHD-graft versus host disease, HGB-hemoglobin, NA-not available.