Table 1.

Summary of studies reporting on the use of various antiviral drugs and antibodies investigated as potential agents for the treatment of SARS-CoV

Drug name	Type	Mechanism of action	References
S230	mAb	Blocking spike protein subunits and ACE2 cellular receptor	[40]
CR3014	mAb	Blocking spike protein subunits and ACE2 cellular receptor	[41]
80R	mAb	Blocking spike protein subunits and ACE2 cellular receptor	[42]
4D4	mAb	Inhibiting the postinteraction in the viral penetration	[43]
F26G19	mAb	Blocking spike protein subunits and ACE2 cellular receptor	[44]
Type 1 interferons	Cytokine	Slowdown of cell metabolism and Adaptive immunity	[14]
Remdesivir	Antiviral drug	Inhibiting viral RNA polymerase action	[16]
Lopinavir	Antiviral drug	Protease inhibitor	[16]
Emetine	Antiprotozoal	Protein synthesis inhibitor	[16]
Homoharringtonine	Anticancer	Protein synthesis inhibitor	[16]
Chloroquine	Antimalarial/antiviral	Increases late endosomal and lysosomal pH	[15]
Ivermectin	Antiparasite/antiviral	Cell hyperpolarization	[45]

ACE2, angiotensin-converting enzyme 2.