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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Addict Biol. 2019 Jul 30;25(2):e12811. doi: 10.1111/adb.12811

Figure 5.

Figure 5.

Drug repositioning analysis supports the involvement of MCOLN1 in the opioid receptor system. (a) Among 83 drug classes, opioid receptor agonist-induced expression profiles display the highest expression similarity score with the MCOLN1 over-expression induced profile in CMap. Expression similarity scores are generated by comparing the MCOLN1 over-expression induced expression profile to the signatures of 83 classes of drug-induced transcription. (b) Single drugs from these top 5 drug classes (highlighted in part a) with expression similarity score >=80 are shown.