Table 1. Genome-wide significant associations for PAU.

The total sample size is 435,563, effective sample size from each cohort was used for sample size weighted meta-analyses (n_effective=300,789) using METAL.

Chr	Pos (hg19)	rsID	Gene	A1	A2	EAF	Z	P	Direction
1	66419905	rs6421482	PDE4Ba	A	G	0.4363	−6.315	2.7×10−10	----
1	73848610	rs61767420	[]	A	G	0.3999	5.714	1.11×10−8	++++
2	27730940	rs1260326	GCKRa	T	C	0.4033	−9.296	1.45×10−20	--+-
2	45141180	rs494904	SIX3b	T	C	0.5961	−7.926	2.26×10−15	----
2	58042241	rs1402398	VRK2b	A	G	0.6274	7.098	1.27×10−12	++++
2	104134432	rs9679319	[]	T	G	0.4797	−6.01	1.86×10−9	----
2	138264231	rs13382553	THSD7Ba	A	G	0.766	−6.001	1.97×10−9	----
2	227164653	rs2673136	IRS1b	A	G	0.6387	−5.872	4.31×10−9	----
3	85513793	rs62250713	CADM2a	A	G	0.368	6.049	1.46×10−9	++++
4	39404872	rs13129401	KLBb	A	G	0.4532	−8.906	5.29×10−19	----
4	100229016	rs75967634	ADH1Ba	T	C	0.003	−6.098	1.07×10−9	--?-
4	100239319	rs1229984	ADH1Ba	T	C	0.0302	−22	2.9×10−107	---?
4	100270452	rs13125415	ADH1Ca	A	G	0.5849	−9.073	1.16×10−19	----
4	103198082	rs13135092	SLC39A8a	A	G	0.9192	11.673	1.75×10−31	++++
7	153489074	rs2533200	DPP6a	C	G	0.5163	−5.631	1.79×10−8	----
8	57424874	rs2582405	PENKb	T	C	0.237	5.751	8.86×10−9	++++
10	72907951	rs7900002	UNC5Bb	T	G	0.6012	−5.503	3.74×10−8	--+-
10	110537834	rs56722963	[]	T	C	0.2551	−6.374	1.85×10−10	----
11	47423920	rs10717830	SLC39A13a	G	GT	0.674	6.422	1.34×10−10	++++
11	57480623	rs576859	TMX2a	A	C	0.3272	5.67	1.43×10−8	+++?
11	113357710	rs138084129	DRD2b	A	AATAT	0.6274	7.824	5.13×10−15	++++
11	113443753	rs6589386	DRD2b	T	C	0.4323	−7.511	5.88×10−14	----
11	121542923	rs1783835	SORL1b	A	G	0.4569	−5.979	2.24×10−9	----
12	51903860	rs12296477	SLC4A8b	C	G	0.5469	5.484	4.15×10−8	++++
14	58765903	rs61974485	ARID4Aa	T	C	0.2646	5.506	3.67×10−8	++++
14	104355883	rs8008020	C14orf2a	T	C	0.4175	6.062	1.35×10−9	++++
16	24693048	rs72768626	TNRC6Aa	A	G	0.9448	5.591	2.26×10−8	++++
16	53820813	rs9937709	FTOa	A	G	0.585	6.602	4.06×10−11	++++
19	49206417	rs492602	FUT2a	A	G	0.5076	−6.143	8.08×10−10	----

Listed are the 29 independent variants that were genome-wide significant. Variants labeled in bold are novel associations with PAU. A1, effect allele; A2, other allele; EAF, effective allele frequency. Directions are for the A1 allele in MVP phase1, MVP phase2, PGC, and UKB datasets.

^aProtein-coding gene contains the lead SNP,

^bProtein-coding gene nearest to the lead SNP.