TABLE 2.

Univariate and multivariate analysis for DSS

Factor	Variable	N	Univariate					Multivariate
			2-year DSS	5-year DSS	HR	CI	P value	HR	CI	P value
Age	≤60	82	74.3	60.1	REF
	>60	159	73.4	55.3	1.134	0.716–1.798	.59
Sex	Male	211	72.8	57.1	REF
	Female	30	81.3	57.7	1.039	0.536–2.016	.91
WUHNCI	0–1	198	77.1	59.2	REF			REF
	>2	43	54.4	44.5	1.813	1.045–3.146	.03	1.660	0.940–2.930	.08
Alcohol	Never	139	76.6	63.8	REF
	Ever	102	70.2	48.0	1.497	0.965–2.322	.07
Tobacco	Never	22	95.0	75.5	REF
	Ever	219	71.6	55.2	2.543	0.930–6.956	.07
Margin Status	Negative	181	77.3	62.9	REF	1.326–3.342	.002	REF
	Positive/close	60	63.2	37.4	2.105			1.697	1.047–2.750	.03
LVI	No	184	79.8	65.5	REF			REF
	Yes	57	54.5	30.5	2.468	1.558–3.910	<.001	1.147	0.677–1.945	.61
PNI	No	135	85.7	71.6	REF			REF
	Yes	106	58.3	37.6	2.817	1.792–4.429	<.001	1.905	1.156–3.142	.01
Site	Glottic	172	79.5	64.9	REF			REF
	Non-Glottic	69	59.6	38.7	2.346	1.504–3.658	<.001	1.854	1.148–2.993	.01
Overall pathological stage (8th edition)	I	55	97.7	94.3	REF			REF
	II	54	80.0	67.2	2.477	0.951–6.451		2.129	0.809–5.604
	III	56	65.7	30.3	6.586	2.717–15.965		4.520	1.797–11.369
	IV	76	57.6	40.7	6.515	2.718–15.618	<.001	4.632	1.886–11.374	.001

Abbreviations: CI, confidence interval; DSS, disease-specific survival; HR, hazard ratio; LVI, lymphovascular invasion; PNI, perineural invasion; REF, reference; WUHNCI, Washington University Head and Neck Comorbidity Index.