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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Head Neck. 2019 Aug 21;41(11):3906–3915. doi: 10.1002/hed.25925

TABLE 2.

Univariate and multivariate analysis for DSS

Factor Variable N Univariate
Multivariate
2-year DSS 5-year DSS HR CI P value HR CI P value
Age ≤60 82 74.3 60.1 REF
>60 159 73.4 55.3 1.134 0.716–1.798 .59
Sex Male 211 72.8 57.1 REF
Female 30 81.3 57.7 1.039 0.536–2.016 .91
WUHNCI 0–1 198 77.1 59.2 REF REF
>2 43 54.4 44.5 1.813 1.045–3.146 .03 1.660 0.940–2.930 .08
Alcohol Never 139 76.6 63.8 REF
Ever 102 70.2 48.0 1.497 0.965–2.322 .07
Tobacco Never 22 95.0 75.5 REF
Ever 219 71.6 55.2 2.543 0.930–6.956 .07
Margin Status Negative 181 77.3 62.9 REF 1.326–3.342 .002 REF
Positive/close 60 63.2 37.4 2.105 1.697 1.047–2.750 .03
LVI No 184 79.8 65.5 REF REF
Yes 57 54.5 30.5 2.468 1.558–3.910 <.001 1.147 0.677–1.945 .61
PNI No 135 85.7 71.6 REF REF
Yes 106 58.3 37.6 2.817 1.792–4.429 <.001 1.905 1.156–3.142 .01
Site Glottic 172 79.5 64.9 REF REF
Non-Glottic 69 59.6 38.7 2.346 1.504–3.658 <.001 1.854 1.148–2.993 .01
Overall pathological stage (8th edition) I 55 97.7 94.3 REF REF
II 54 80.0 67.2 2.477 0.951–6.451 2.129 0.809–5.604
III 56 65.7 30.3 6.586 2.717–15.965 4.520 1.797–11.369
IV 76 57.6 40.7 6.515 2.718–15.618 <.001 4.632 1.886–11.374 .001

Abbreviations: CI, confidence interval; DSS, disease-specific survival; HR, hazard ratio; LVI, lymphovascular invasion; PNI, perineural invasion; REF, reference; WUHNCI, Washington University Head and Neck Comorbidity Index.