TABLE 2.
Factor | Variable | N | Univariate |
Multivariate |
||||||
---|---|---|---|---|---|---|---|---|---|---|
2-year DSS | 5-year DSS | HR | CI | P value | HR | CI | P value | |||
Age | ≤60 | 82 | 74.3 | 60.1 | REF | |||||
>60 | 159 | 73.4 | 55.3 | 1.134 | 0.716–1.798 | .59 | ||||
Sex | Male | 211 | 72.8 | 57.1 | REF | |||||
Female | 30 | 81.3 | 57.7 | 1.039 | 0.536–2.016 | .91 | ||||
WUHNCI | 0–1 | 198 | 77.1 | 59.2 | REF | REF | ||||
>2 | 43 | 54.4 | 44.5 | 1.813 | 1.045–3.146 | .03 | 1.660 | 0.940–2.930 | .08 | |
Alcohol | Never | 139 | 76.6 | 63.8 | REF | |||||
Ever | 102 | 70.2 | 48.0 | 1.497 | 0.965–2.322 | .07 | ||||
Tobacco | Never | 22 | 95.0 | 75.5 | REF | |||||
Ever | 219 | 71.6 | 55.2 | 2.543 | 0.930–6.956 | .07 | ||||
Margin Status | Negative | 181 | 77.3 | 62.9 | REF | 1.326–3.342 | .002 | REF | ||
Positive/close | 60 | 63.2 | 37.4 | 2.105 | 1.697 | 1.047–2.750 | .03 | |||
LVI | No | 184 | 79.8 | 65.5 | REF | REF | ||||
Yes | 57 | 54.5 | 30.5 | 2.468 | 1.558–3.910 | <.001 | 1.147 | 0.677–1.945 | .61 | |
PNI | No | 135 | 85.7 | 71.6 | REF | REF | ||||
Yes | 106 | 58.3 | 37.6 | 2.817 | 1.792–4.429 | <.001 | 1.905 | 1.156–3.142 | .01 | |
Site | Glottic | 172 | 79.5 | 64.9 | REF | REF | ||||
Non-Glottic | 69 | 59.6 | 38.7 | 2.346 | 1.504–3.658 | <.001 | 1.854 | 1.148–2.993 | .01 | |
Overall pathological stage (8th edition) | I | 55 | 97.7 | 94.3 | REF | REF | ||||
II | 54 | 80.0 | 67.2 | 2.477 | 0.951–6.451 | 2.129 | 0.809–5.604 | |||
III | 56 | 65.7 | 30.3 | 6.586 | 2.717–15.965 | 4.520 | 1.797–11.369 | |||
IV | 76 | 57.6 | 40.7 | 6.515 | 2.718–15.618 | <.001 | 4.632 | 1.886–11.374 | .001 |
Abbreviations: CI, confidence interval; DSS, disease-specific survival; HR, hazard ratio; LVI, lymphovascular invasion; PNI, perineural invasion; REF, reference; WUHNCI, Washington University Head and Neck Comorbidity Index.