TABLE 2:

Study Characteristics

Study	Publication Year	Country	Study Design	Consecutive Enrollment	Multicenter Study	No. of MRI Readers	EMVI Assessment at MRI	Definition of EMVI at Pathologic Examination
Brown et al. [15]	2003	United Kingdom	Prospective	Yes	No	2	Presence or absence of tumor signal within or invasion of vascular structure	Confined to venous invasion
Smith et al. [10]	2008	United Kingdom	Retrospective	Yes	No	1	5-Point scoring systema	Confined to venous invasion
Rollvén et al. [9]	2013	Sweden	Retrospective	Yes	No	2	Not specified	Not specified
Sohn et al. [25]	2015	Korea	Retrospective	Yes	No	2	5-Point scoring systema	Lymphovascular invasion
Chand et al. [12]	2015	United Kingdom	Retrospective	Yes	No	1	5-Point scoring systema	Confined to venous invasion
Hunter et al. [26]	2016	United Kingdom	Prospective	Yes	Yes	2	Presence or absence of tumor signal within or invasion of vascular structure	Not specified
Jhaveri et al. [27]	2016	Canada	Retrospective	Yes	No	2	5-Point scoring systema	Confined to venous invasion
Liu et al. [13]	2016	China	Retrospective	Yes	No	2	5-Point scoring systema	Confined to venous invasion
Yu et al. [28]	2016	China	Retrospective	Yes	No	2	5-Point scoring systema	Lymphovascular invasion
Dam et al. [29]	2017	Denmark	Retrospective	Yes	No	2	Presence or absence of tumor signal within or invasion of vascular structure	Not specified
Nerad et al. [16]	2017	The Netherlands	Retrospective	Yes	No	2	Presence or absence of tumor signal within or invasion of vascular structure	Not specified
El-Kady et al. [30]	2018	Egypt	Retrospective	Not specified	No	NA	Not specified	Confined to venous invasion
Lee et al. [31]	2018	Korea	Retrospective	Yes	No	2	5-Point scoring systema	Confined to venous invasion
Poulsen et al. [17]	2018	Denmark	Retrospective	Yes	No	4	Not specified	Not specified

Note—EMVI = extramural venous invasion, NA = not available.

^aFive-point scoring system (0–4) for assessing EMVI at MRI proposed by Smith et al. [10].