Normalized (to 1) peptide-level LITPOMS responses for selected peptides and residue showing increases in protection (decreases in modification) for peptides 125-138, peptide 90-99, residue M51 and peptide 14-30 representing EF hands 4 – 1 of CaM, respectively. The insert shows expanded decreases in modification for peptide 90-99, residue M51 and peptide 14-30. Data are averages of two independent runs, and error bars are standard deviations and are normalized accordingly. The relatively large standard deviations for EF-3 (90-99) are discussed in SI.