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Regions identified by HDX and FPOP show good agreement with those identified by the crystal structure of the complex.
| Contact Region (residue #) |
Observed in X-ray* | Identified by HDX | Identified by FPOP |
|---|---|---|---|
| 18(N-terminal)-28 | None | 18-28 | 18-25 |
| 46-87 | 54-56, 63, 66-68, 71, 73, 76 | 57-87 | 47-75 |
| 113-125 | 113, 115, 121, 123 | 116-122 | 114-125 |
A heavy-atom to heavy-atom distance cut off of less than or equal to 4 Å was used to select residues in close contact to the macrocycle.
