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(a) A cartoon structure of an ABPP probe containing a core unit (triangle), a linker, and a reporter tag (oval). The core unit contains a pharmacophore and a “warhead” that enable covalent attachment of the probe to the complex. Linker is used to modulate the space between core unit and reporter tag, which facilitates downstream protein enrichment and analysis. (b) Common ABPP probe warheads containing fluorine.
