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Structure of selected FMK probes starting with adenine, 13. FMK is incorporated at adenine 2-position to make 14. A compact gatekeeper (e.g., threonine) in a kinase allows compounds with bulky aromatics at the 3-position (14) to enter the kinase hydrophobic pocket. Cell-membrane permeability is improved after installing a BODIPY group to give 15.
