Figure 2: Therapeutic strategies targeting mutant p53.

Strategies targeting mutant p53 include the following: (i) restoring mutant p53 to wild-type p53 structure and function; (ii) destabilizing mutant p53 to deplete the protein; (iii) inhibition of the interactions of mutant p53 with its binding partners to dampen transcriptional regulatory activity; and iv) targeting mutant p53 downstream pathways. Future strategy may involve adoptive T cell therapy against mutant p53 neoepitopes.