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Autophagic markers in the brain of 3xTg-AD mice. Beclin-1 and LC3 II expression in brain homogenates of 3xTg-AD mice (panel A). GAPDH was used as a control to check equal protein loading (*p<0.05, **p<0.01 and ***p<0.001 vs T0, ###p<0.001 vs C, §§p<0.01 and §§§p<0.001 vs LAB). Cathepsin L and B activity measured in brain homogenates of 3xTg-AD mice, T0, C, LAB and p62-LAB groups (panel B) (**p<0.01 and ***p<0.001 vs T0, ##p<0.01 and ###p<0.001 vs C, §§p<0.01 vs LAB).
