Table 2. Model descriptions.
| Outcome | Exposure (Epigenetic Aging Measure) | |
| AAD, EEAD | ΔAAD, ΔEEAD | |
| Lung Function (FEV1, FVC, FEV1/FVC, FEF25-75) | age, sex, smoking status, height, weight, baseline COPD, baseline asthma | age, sex, smoking status, height, weight, baseline COPD, baseline asthma, years between examinations, baseline epigenetic age (AAD, EEAD) |
| COPD | age, sex, smoking status, height, weight | age, sex, smoking status, height, weight, years between examinations, baseline epigenetic age (AAD, EEAD) |
List of the covariates adjusted for in each combination of outcomes and epigenetic aging measures (exposures) examined. Age, sex, smoking status, height, and weight were included in all models. Models for lung function variables additionally included baseline COPD and asthma. Models for the change in epigenetic age over time (ΔAAD, ΔEEAD) additionally adjusted for baseline epigenetic age (AAD or EEAD for ΔAAD and ΔEEAD models respectively) as well as the follow up time (years between examinations. AAD = age acceleration difference; COPD = chronic obstructive pulmonary disease; EEAD = extrinsic epigenetic age acceleration difference; FEF27-75 = forced expiratory flow at 25-75% of pulmonary volume; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity.