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. 2020 Aug 24;12(16):16072–16082. doi: 10.18632/aging.103522

Table 3. Univariate and multivariate linear regression of risk factors associated with liver stiffness measurement.

Variables Univariate analysis Multivariate analysis
β Standard error P-value β Standard error P-value
Entire CHB Cohort (n=330)
Age (years) -0.124 0.577 0.024 0.070 0.026 0.169
Sex 0.058 0.028 0.295
ALT (IU/L) 0.353 0.008 <0.001 0.241 0.009 <0.001
GGT (U/L) 0.346 0.008 <0.001 0.161 0.009 0.007
ALP (U/L) 0.171 0.011 0.002 0.041 0.011 0.430
TB (μ/L) 0.088 0.045 0.112
TC(mmol/L) -0.009 0.261 0.875
BMI (kg/m2) 0.264 0.081 <0.001 0.097 0.101 0.147
CAP (dB/m) 0.28 0.008 <0.001 0.116 0.010 0.085
S0-1 CHB (n=227)
Age (years) 0.036 0.022 0.590
Sex 0.005 0.426 0.937
ALT (IU/L) 0.299 0.008 <0.001 0.209 0.008 0.004
GGT (U/L) 0.247 0.008 <0.001 0.059 0.009 0.417
ALP (U/L) 0.055 0.009 0.412
TB (μ/L) 0.053 0.032 0.430
TC (mmol/L) 0.064 0.188 0.337
BMI (kg/m2) 0.274 0.060 <0.001 0.103 0.079 0.227
CAP (dB/m) 0.323 0.006 <0.001 0.179 0.008 0.041
S2-4 CHB (n=103)
Age (years) -0.003 0.066 0.979
Sex -0.229 1.391 0.020 -0.140 1.393 0.152
ALT (IU/L) 0.289 0.015 0.003 0.203 0.016 0.050
GGT (U/L) 0.288 0.014 0.003 0.119 0.016 0.267
ALP (U/L) 0.095 0.026 0.338
TB (μ/L) 0.084 0.119 0.398
TC (mmol/L) -0.057 0.656 0.569
BMI (kg/m2) 0.277 0.191 0.005 0.140 0.239 0.246
CAP (dB/m) 0.217 0.019 0.028 0.092 0.023 0.436

ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; ALP, alkaline phosphatase; TB, total bilirubin; BMI, body mass index; CAP, controlled attenuation parameter; TC, total cholesterol