Table 4. Different optimal cutoff values for different fibrosis stage in different CAP groups.
| Fibrosis stage | AUROC (95%CI) | Parameter | Cutoff (KPa) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Diagnostic accuracy (%) | LR (+) | LR (-) |
| All cases | ||||||||||
| Sn | 4.7 | 90.09 | 16.95 | 66.09 | 48.77 | 63.94 | 1.08 | 0.58 | ||
| S1 | 0.65 | Sp | 10.1 | 30.66 | 90.68 | 85.53 | 42.13 | 52.12 | 3.29 | 0.76 |
| (0.60-0.71) | Youden Index | 8.6 | 48.11 | 81.36 | 82.26 | 46.60 | 59.70 | 2.58 | 0.64 | |
| Sn | 5.8 | 90.29 | 33.04 | 37.96 | 88.24 | 50.91 | 1.35 | 0.29 | ||
| S2 | 0.77 | Sp | 10.6 | 43.69 | 90.31 | 67.17 | 77.95 | 75.76 | 4.51 | 0.62 |
| (0.72-0.83) | Youden Index | 8.9 | 64.08 | 79.30 | 58.41 | 82.95 | 74.55 | 3.09 | 0.45 | |
| Sn | 6.0 | 90.91 | 32.17 | 17.09 | 95.84 | 39.70 | 1.34 | 0.28 | ||
| S3 | 0.77 | Sp | 12.1 | 50.00 | 90.21 | 43.99 | 92.15 | 84.85 | 5.11 | 0.55 |
| (0.69-0.85) | Youden Index | 10.1 | 61.36 | 82.87 | 35.52 | 93.31 | 86.67 | 3.58 | 0.47 | |
| Sn | 6.0 | 94.12 | 29.71 | 6.78 | 98.94 | 33.03 | 1.34 | 0.20 | ||
| S4 | 0.79 | Sp | 12.9 | 52.94 | 90.10 | 22.50 | 97.24 | 88.18 | 5.35 | 0.52 |
| (0.67-0.91) | Youden Index | 10.1 | 70.59 | 79.55 | 15.78 | 98.03 | 79.09 | 3.45 | 0.37 | |
| CAP<248 | ||||||||||
| S1 | 0.66 | Sn | 4.5 | 90.32 | 15.05 | 63.93 | 48.26 | 62.10 | 1.06 | 0.64 |
| (0.59-0.73) | Sp | 9.0 | 40.00 | 90.32 | 87.32 | 47.46 | 58.87 | 4.13 | 0.66 | |
| Youden Index | 8.6 | 43.23 | 89.25 | 87.02 | 48.54 | 60.48 | 4.02 | 0.64 | ||
| S2 | 0.78 | Sn | 5.5 | 90.41 | 34.29 | 36.47 | 89.55 | 50.81 | 1.38 | 0.28 |
| (0.71-0.85) | Sp | 9.5 | 53.42 | 90.29 | 69.65 | 82.29 | 79.44 | 5.50 | 0.52 | |
| Youden Index | 8.9 | 61.64 | 84.57 | 62.50 | 84.09 | 77.82 | 4.00 | 0.45 | ||
| S3 | 0.77 | Sn | 5.9 | 91.18 | 35.51 | 18.34 | 96.20 | 43.15 | 1.41 | 0.25 |
| (0.68-0.87) | Sp | 10.9 | 47.06 | 90.19 | 43.25 | 91.47 | 84.27 | 4.80 | 0.59 | |
| Youden Index | 10.1 | 58.82 | 87.38 | 42.55 | 93.03 | 83.47 | 4.66 | 0.47 | ||
| S4 | 0.76 | Sn | 6.0 | 92.31 | 34.47 | 7.23 | 98.78 | 37.10 | 1.41 | 0.22 |
| (0.63-0.90) | Sp | 12.1 | 46.15 | 90.21 | 20.68 | 96.80 | 87.90 | 4.72 | 0.60 | |
| Youden Index | 10.1 | 61.54 | 83.40 | 17.01 | 97.51 | 82.26 | 3.71 | 0.46 | ||
| CAP≥248 | ||||||||||
| S1 | 0.58 | Sn | 5.7 | 91.23 | 20.00 | 72.22 | 50.01 | 69.51 | 1.14 | 0.44 |
| (0.45-0.71) | Sp | 12.6 | 29.82 | 92.00 | 89.47 | 36.51 | 48.78 | 3.73 | 0.76 | |
| Youden Index | 14.8 | 26.32 | 96.00 | 93.75 | 36.37 | 30.49 | 6.58 | 0.77 | ||
| S2 | 0.72 | Sn | 8.0 | 90.00 | 48.08 | 50.01 | 89.28 | 63.41 | 1.73 | 0.21 |
| (0.61-0.84) | Sp | 12.6 | 46.67 | 90.38 | 73.68 | 74.60 | 74.39 | 4.85 | 0.59 | |
| Youden Index | 8.0 | 90.00 | 48.08 | 50.01 | 89.28 | 63.41 | 1.73 | 0.21 | ||
| S3 | 0.80 | Sn | 8.3 | 90.00 | 43.06 | 18.01 | 96.87 | 48.78 | 1.58 | 0.23 |
| (0.66-0.94) | Sp | 19.0 | 30.00 | 90.28 | 30.01 | 90.27 | 82.93 | 3.09 | 0.78 | |
| Youden Index | 16.4 | 70.00 | 88.89 | 46.68 | 95.52 | 86.59 | 6.30 | 0.34 | ||
| S4 | 0.91 | Sn | 16.4 | 100.00 | 85.90 | 26.68 | 100.00 | 86.59 | 7.09 | 0.00 |
| (0.84-0.98) | Sp | 20.0 | 50.00 | 91.03 | 22.24 | 97.26 | 89.02 | 5.57 | 0.55 | |
| Youden Index | 16.4 | 100.00 | 85.90 | 26.68 | 100.00 | 86.59 | 7.09 | 0.00 |