Study |
Sample size |
Mean D-dimer (<0.5 μg/ml) |
p-values |
Comment |
Tang et al, Feb 2020,[34] |
Survivors (162) |
0.6 |
<0.001 |
Disseminated intravascular coagulation (DIC) was found in most deaths |
Non-survivors (21) |
2.12 |
Han et al, Mar 2020, [33] |
Ordinary patient (49) |
2.14 ±2.88 |
<0.001 |
Huge increase in D-dimer in critically ill COVID patients |
Critical (10) |
20.04 ± 32.39 |
<0.05 |
Wang et al, Mar 2020, [46] |
ICU (36) |
4.14 |
<0.001 |
In the non-survivors, D-dimer increased continuously |
Non-ICU (102) |
1.66 |
Zhang et al, April 2020, [47] |
Ordinary (276) |
0.41 |
<0.001 |
12 non-survivors had D-dimer values greater than 2.0 |
Severe (67) |
4.76 |
Spiezia et al, April 2020, [48] |
ICU (22) |
5.343 ±2.099 |
<0.0001 |
All ICU patients with acute respiratory failure showed severe hypercoagulability, one patient with the most hypercoagulable state died. |
Ranucci et al, April 2020, [35] |
Total (16) |
3.5 |
0.017 |
Seven patients died of hypoxia and multi-organ failure |
Tang et al, May 2020, [49] |
Survivors (315) |
1.47 |
<0.001 |
30 of the non survivors died even after treated with low molecular weight heparin |
Non-survivors (134) |
4.7 |