Table 1. Regulation of individual ATP synthase subunit protein expression levels across different tissue samples from different AD models, summarising data presented in this review.
Model | Tissue | α-subunit | β-subunit | OSCP | Subunit d | δ-subunit | Reference |
Aβ injected rat | Hippocampus | Down | Shi, X. et al., 2011 | ||||
SweAPP Tg mice | Whole brain homogenate | Up | Carrette, O. et al., 2006 | ||||
4 months old 5xFAD mice | Synaptic mitochondria | Down | Beck, S. J. et al., 2016 | ||||
9 months old 5xFAD mice | Synaptic mitochondria | Down | Beck, S. J. et al., 2016 | ||||
Non-synaptic mitochondria | Down | Beck, S. J. et al., 2016 | |||||
3x Tg AD mouse | Hippocampus | Down | Yu, H. et al., 2018 | ||||
AD patient | Temporal lobe | Down | Beck, S. J. et al., 2016 | ||||
Medial frontal gyrus | Down | Adav, S. S. et al., 2019 | |||||
Temporal cortex | Down | Mukherjee, S. et al., 2017 | |||||
Frontal cortex | Up | Manczak, M. et al., 2004 |