Table 1. Combination and does-reduction index of chidamide and ibrutinib.

Fa		MEC-1				JVM-3
		CI value	DRI IB	DRI CHI		CI value	DRI IB	DRI CHI
0.5		0.35	4.44	7.98		0.50	4.11	3.91
0.75		0.35	4.75	7.43		0.38	6.37	4.50
0.9		0.34	5.09	6.93		0.29	9.87	5.17
0.95		0.34	5.33	6.61		0.25	13.29	5.69
0.97		0.34	5.51	6.40		0.23	16.43	6.09

Fa: Fraction Affected

CI: Combination Index; additive effect (CI=1), synergism (CI<1), and antagonism (CI>1)

DRI: dose-reduction index

IB: Ibrutinib

CHI: Chidamide