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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Recent Pat Anticancer Drug Discov. 2010 Jun;5(2):99–108. doi: 10.2174/157489210790936252

Fig. (1). Mechanism of Peptide Membrane Transduction.

Fig. (1).

1) CPP-Cargo peptide is delivered to the site of disease. 2) The CPP’s highly cationic amino acids interact with proteoglycans (left) or glycolipids (right) on the cell surface. Note: There is an evidence that the CPP-cargo directly enters the cell (center arrow) 3) The peptide is endocytosed via clathrin or caveoloae or it is macropinocytosed. 4) Endosomal escape of peptide. 5) Interaction with target protein.