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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Recent Pat Anticancer Drug Discov. 2010 Jun;5(2):99–108. doi: 10.2174/157489210790936252

Fig. (2). Mechanism of CTT Anti-Cancer Therapy.

Fig. (2).

1) The CPP portion of the CTT attaches to the plasma membrane and directly inhibits ECM Receptor/ECM interaction. This inhibits the ability of metastatic cancer cells to establish secondary tumor sites. 2) CTTs block cancer dependent protein-protein interactions, resulting in the inhibition of proliferation, angiogenesis, and chemoresistance. 3) Additionally, inhibition of protein interactions can modulate nuclear translocation of oncogenic transcription factors.