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. 2020 Sep 11;15(9):e0239094. doi: 10.1371/journal.pone.0239094

Fig 1. Effects of intrathecal administration of ML297 on mechanical nociception.

Fig 1

(A) ML297 increased the paw withdrawal threshold in a dose-dependent manner. Significant effects were seen at 3 μg and higher doses. Data are mean±SEM of the pre-injection baseline levels (n = 6 rats/group). *P<0.01, #P<0.001, compared to the vehicle at corresponding time points. (B) Effects of intrathecally administered ML297 on motor performance in the rotarod test. ML297 did not affect motor performance at concentrations up to 100 μg. Data are mean±SEM (n = 6 rats/group).