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. 2020 Sep 11;15(9):e0239094. doi: 10.1371/journal.pone.0239094

Fig 4. Effects of ML297 on mEPSCs.

Fig 4

(A) Representative recording of mEPSCs before (left) and after (right) administration of 100 μM ML297. (B) Cumulative distribution of the inter-event interval and amplitude of mEPSCs recorded before application (grey line) and in the presence (black line) of 100 μM ML297. ML297 did not affect the distribution of the amplitude (P = 0.99, right), but shifted the distribution to a longer inter-event interval (P<0.05, left). (C) Summary of normalized frequencies (left) and amplitudes (right) of mEPSCs relative to the pre-application base line levels. ML297 at 100 μM, but not at lower concentrations of 10 and 1 μM, significantly decreased the frequency of mEPSCs. ML297 had no significant effect on mEPSC amplitude irrespective of the concentration. Data are mean±SEM (n = 8).