Fig 5. Effects of naloxone on presynaptic and postsynaptic actions of ML297.

(A) Representative recording of currents applied by DAMGO in the absence (left) and presence (middle) of naloxone and currents applied by ML297 in the presence of naloxone (right). The readings were obtained from the same neuron (n = 7, V_H = -70 mV). (B) Summary of normalized amplitudes of DAMGO and ML297-induced outward currents. The peak of the DAMGO-induced current was set as a reference value (control). (C) Summary of normalized frequencies of mEPSCs for each condition. Data in (B) and (C) are mean±SEM (n = 7, each). ^★P<0.05, n.s.; not significant.