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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Nat Rev Cancer. 2018 Feb 16;18(5):283–295. doi: 10.1038/nrc.2018.10

Figure 5 ∣. Microbiota injury and complications after allo-HSCT.

Figure 5 ∣

The top panels summarize the profiles of healthy microbiota before and after allogeneic haematopoietic stem cell transplantation (allo-HSCT) compared with those of injured microbiota after allo-HSCT. Microbiota injury results in infections, malignant relapse, graft-versus-host disease (GVHD) and possibly delayed immune reconstitution that contributes to additional infections (cytomegalovirus (CMV) infection and/or certain types of pneumonia that require adaptive immunity to eradicate). All of these can then contribute to reduced overall survival of patients after allo-HSCT.