Table 3. Other Serious Adverse Events - All Events Are Reported as Percentages (%) .
Cs-131: Cesium-131; CSF: cerebral spinal fluid; CVA: cerebrovascular accident; HGG: high-grade glioma; HCP: hydrocephalus; ICH: intracerebral hemorrhage; I-125: Iodine-125; Ir-192: Iridium-192; Mening: meningioma; Mets: metastases; NPH: normal pressure hydrocephalus
| Study | Tumor Type | Type of Implant | Source | Wound Healing | CSF Leak | Meningitis | Wound Infection | ICH | Seizures | Poor Seed placement | CVA | NPH/HCP | Hygroma | |
| 1 | Chan et al. [16] | HGG | Intracavitary | I-125 GliaSite | 4.2 | – | – | – | – | – | – | – | – | – |
| 2 | Gabayan et al. [17] | HGG | Intracavitary | I-125 GliaSite | 2 | 3 | – | 2 | – | 2 | – | 1 | 1 | 1 |
| 3 | Tselis et al. [29] | HGG | Interstitial | Ir-192 | – | – | 1.2 | – | 2.4 | – | – | – | – | – |
| 4 | Darakchiev et al. [5] | HGG | Intracavitary | I-125 | 12 | – | – | – | – | – | – | – | – | – |
| 5 | Fabrini et al. [28] | HGG | Intracavitary | Ir-192 | 9.5 | 9.5 | – | – | 5 | – | – | – | – | – |
| 6 | Gobitti et al. [18] | HGG | Intracavitary | I-125 GliaSite | – | – | – | – | – | – | – | – | – | 6.7 |
| 7 | Archavlis et al. [26] | HGG | Interstitial | Ir-192 | 4.3 | 4.3 | 4.3 | – | – | – | – | – | – | – |
| 8 | Schwartz et al. [25] | HGG | Interstitial | 1-125 | 2.9 | – | – | – | – | – | 2.9 | – | – | – |
| 9 | Chatzikonstantinou et al. [27] | HGG | Interstitial | Ir-192 | – | – | – | – | 6 | 0.7 | – | – | – | – |
| 10 | Magill et al. [21] | Mening | Intracavitary | I-125 | 14 | – | – | 7 | – | – | – | – | 8 | 5 |
| 11 | Brachman et al. [3] | Mening | Intracavitary | Cs-131 | 10 | – | – | – | – | 5 | – | – | – | 5 |
| 12 | Koch et al. [20] | Mening | Intracavitary | I-125/Cs-131 | 40 | – | – | – | – | – | – | – | – | – |
| 13 | Mooney et al. [22] | Mening | Intracavitary | I-125/Cs-131 | 9 | – | – | – | – | 27 | – | – | – | 9 |
| 14 | Huang et al. [19] | Mets | Intracavitary | I-125 | – | – | – | – | – | – | – | – | – | 13 |
| 15 | Ruge et al. [24] | Mets | Interstitial | I-125 | 3.7 | – | – | – | – | – | – | – | – | – |
| 16 | Raleigh et al. [23] | Mets | Intracavitary | I-125 | 6 | – | – | – | – | – | – | – | – | – |