Table 6.
Some sources of genetic toxicology data (non-exhaustive list).*
| Database | Description |
|---|---|
| ATSDR | Open access database from the Agency for Toxic Substances and Disease Registry (ATSDR) includes toxicological profiles for the hazardous substances including genotoxicity (ATSDR, 2018) |
| CCRIS | Chemical Carcinogenesis Research Information System (CCRIS), open access database covering chemical carcinogens and genotoxicants, including structures and experimental data, covering the period 1985 – 2011 (CCRIS, 2011) |
| Drugs@FDA | Open access database from US FDA CDER product approval reviews (FDA, 2018) |
| EPA Comptox Dashboard | Open access Distributed Structure-Searchable Toxicity (DSSTox) Database Network from the United States Environmental Protection Agency (EPA) including content from other sources (e.g., CPDB, ISSCAN, Tox21 and ToxCast) |
| ECHA | Open access European Chemicals Agency (ECHA) database containing experimental data and read across results for chemicals manufactured and imported in Europe as regulated by the REACH guidance (ECHA, 2018) |
| ELSIE | The Extractables and Leachables Safety Information Exchange (ELSIE) database is a collection of experimental data shared and accessed by consortium members (ELSIE, 2018) |
| EURL ECVAM | Open access Genotoxicity & Carcinogenicity consolidated database containing available genotoxicity and carcinogenicity data for Ames positive compounds (European Commission, 2018a) |
| GENE-TOX | GENE-TOX provides genetic toxicology (mutagenicity) test data from expert peer review of open scientific literature for more than 3,000 chemicals from the EPA (GENE-TOX, 1998). GENETOX covers the years 1991 – 1998. |
| IPS INCHEM | Open access International Program on Chemical Safety search for variety of summary documents (INCHEM, 2015) |
| IRIS | Open access data from the EPA in support of human health risk assessment, focusing on hazard identification and dose-response assessment (IRIS, 2015) |
| ISSCAN | Open access database on chemical carcinogens, including structures and experimental data from Istituto Superiore di Sanità (Benigni et al., 2008) |
| ISSMIC | Open access database on in vivo micronucleus mutagenicity results from Istituto Superiore di Sanità (Benigni and Bossa, 2008; Benigni et al., 2012) |
| JECDB | Open access Japanese Existing Chemical Data Base (JECDB) containing high production volume chemicals (JECDB, 2018) |
| Leadscope | Commercial genetic toxicity databases from numerous sources (including US FDA CDER product approval reviews, FDA CFSAN, National Toxicology Program (NTP), CCRIS) as well as ongoing data harvesting from the literature (Leadscope, 2018) |
| NTP – CEBS | Chemical Effects in Biological Systems (CEBS). Open access database of NTP results (NTP, 2018) |
| PAN | Open access Pesticide Action Network (PAN) Pesticide Database (PAN, 2018) |
| PharmaPendium | Commercial preclinical toxicity and clinical safety data from FDA and EMA approval documents (PharmaPendium, 2018) |
| RTECS | Registry of Toxic Effects of Chemicals (RTECS). Commercial database available through third parties (e.g., Leadscope) (Sweet et al., 1999; RTECS, 2018) |
| TOXNET/ChemIDPlus | Open access on-line toxicity search system from the US National Library of Medicine with access to archived versions of CCRIS and GENE-TOX (Wexler, 2001; TOXNET, 2018) |
| OECD QSAR Toolbox | Open access to database of genotoxicity as well as other toxicology data. (OECD, 2019) |
| VITIC | Commercial database from Lhasa Limited, including data from published and unpublished sources (VITIC, 2018) |
*
Modified from Amberg et al. (Amberg et al., 2016)