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. 2020 Apr 8;13(5):923–931. doi: 10.1111/cts.12779

Figure 3.

Figure 3

Zanubrutinib C‐QTc analysis. (a) Scatter plot of observed zanubrutinib plasma concentrations and mean change from baseline in QTcF interval over time using Fridericia’s formula (ΔΔQTcF) and (b) mean (90% confidence interval (CI)) model‐predicted and observed ΔΔQTcF across deciles of zanubrutinib plasma concentrations. (a) The solid red line with dashed red curves above and below denotes the model‐predicted mean (90% CI) ΔΔQTcF. The blue squares and red triangles denote the pairs of observed zanubrutinib plasma concentrations and ΔΔQTcF by participants for the 160‐mg and 480‐mg doses of zanubrutinib, respectively. (b) The red dots with vertical bars denote the observed mean (90% CI) ΔΔQTcF at the median zanubrutinib plasma concentration within each decile. The solid black line within the gray shaded area denotes the model‐predicted mean (90% CI) ΔΔQTcF. The horizontal red line with notches shows the range of concentrations divided into deciles for zanubrutinib. The area between each decile represents the point at which 10% of the data are present; the first notch to second notch denotes the first 10% of the data, the second notch to third notch denotes the second 10%, and so on.