Table 2.
Predicted ΔΔQTcF interval at geometric mean peak zanubrutinib concentration (PK/QTc population)
| Treatment | n | Geometric mean Cmax (90% CI), ng/mL | Predicted (90% CI) ΔΔQTcF, msec |
|---|---|---|---|
| Zanubrutinib 160 mg | 27 | 215.4 (198.96 to 233.29) | −3.16 (−4.51 to −1.81) |
| Zanubrutinib 480 mg | 28 | 401.1 (363.37 to 442.82) | −3.38 (−4.86 to −1.89) |
ΔΔQTcF, placebo‐corrected change‐from‐baseline QT interval corrected for heart rate with Fridericia’s formula; CI, confidence interval, Cmax, maximum observed concentration; PK, pharmacokinetic, QTc, QT interval corrected for heart rate.