Table 2.
Laboratory findings of patients infected with SARS-CoV-2 on admission to hospital (N=175).
| Variable | Normal range |
Values by disease severity, mean (95% CI) | P value | |||
|
|
|
Mild | Moderate | Severe | Critical |
|
| White blood cell count, ×109/L | 3.5-9.5 | 5.16 (4.47 to 5.86) | 4.73 (4.39 to 5.07) | 5.37 (4.1 to 6.64) | 5.22 (4.69 to 5.75) | .35 |
| Neutrophil count, ×109/L | 1.8-6.3 | 2.98 (2.35 to 3.61) | 2.62 (2.38 to 2.87) | 3.95 (2.64 to 5.26) | 3.83 (3.31 to 4.35) | <.001 |
| Lymphocyte count, ×109/L | 1.1-3.2 | 1.55 (1.33 to 1.77) | 1.58 (1.41 to 1.74) | 1.02 (0.78 to 1.26) | 0.96 (0.82 to 1.09) | <.001 |
| Platelet count, ×109/L | 125-350 | 209.2 (182.7 to 235.7) | 208.1 (194.4 to 221.7) | 211.9 (169.9 to 253.9) | 186.9 (171.0 to 202.7) | .19 |
| C-reactive protein, mg/L | 0-5 | 4.99 (1.02 to 8.95) | 9.21 (5.87 to 12.55) | 31.1 (13.98 to 48.22) | 43.24 (32.70 to 53.77) | <.001 |
| Alanine aminotransferase, U/L | 9-50 | 24.93 (15.78 to 34.07) | 22.15 (17.26 to 27.05) | 29.67 (20.58 to 38.75) | 28.64 (23.13 to 34.15) | .28 |
| Aspartate aminotransferase, U/L | 15-40 | 24.85 (20.06 to 29.64) | 22.85 (20.40 to 25.30) | 29.61 (22.93 to 36.29) | 33.24 (28.66 to 37.82) | <.001 |
| Urea, mmol/L | 3.1-8.0 | 3.71 (3.11 to 4.3) | 4.05 (3.79 to 4.3) | 6.17 (4.6 to 7.74) | 5.74 (4.36 to 7.12) | .003 |
| Creatinine, μmol/L | 57-97 | 52.41 (46.13 to 58.68) | 54.44 (51.71 to 57.18) | 68.06 (54.75 to 81.36) | 94.14 (50.26 to 138.0) | .1 |
| Lactate dehydrogenase, U/L | 120-250 | 186.2 (165.1 to 207.2) | 193.8 (182.4 to 205.2) | 242.1 (201.1 to 283.0) | 294.1 (262.7 to 325.5) | <.001 |
| Creatine kinase, U/L | 50-310 | 64.96 (24.26 to 105.7) | 71.03 (58.94 to 83.11) | 87.67 (45.81 to 129.5) | 123.4 (83.10 to 163.7) | .03 |
| CD3 (%) | 56-86 | 72.15 (68.45 to 75.84) | 70.8 (68.62 to 72.99) | 67.68 (61.38 to 73.99) | 58.19 (54.36 to 62.03) | <.001 |
| CD3 count, /μL | 723-2737 | 1124 (923.0 to 1326) | 1036 (933.0 to 1140) | 658.4 (465.9 to 851.0) | 577.1 (460.1 to 694.1) | <.001 |
| CD4 (%) | 33-58 | 41.71 (38.81 to 44.61) | 41.19 (39.18 to 43.20) | 41.85 (37.44 to 46.26) | 31.91 (29.23 to 34.60) | <.001 |
| CD4 count, /μL | 404-1612 | 669.9 (573.6 to 766.3) | 610.8 (544.8 to 676.7) | 402.7 (288.5 to 517.0) | 315 (247.2 to 382.7) | <.001 |
| CD8 (%) | 13-39 | 27.06 (24.62 to 29.51) | 25.75 (24.41 to 27.08) | 22.64 (18.63 to 26.64) | 23.98 (20.97 to 26.98) | .21 |
| CD8 count, /μL | 220-1129 | 444.3 (355.1 to 533.5) | 369.8 (328.7 to 410.8) | 227.6 (151.7 to 303.4) | 237.9 (183.9 to 291.9) | <.001 |
| CD4/CD8 ratio | 0.9-2.0 | 1.64 (1.43 to 1.85) | 1.93 (1.46 to 2.4) | 2.55 (1.28 to 3.81) | 1.63 (1.38 to 1.87) | .17 |
| CD19 (%) | 5-22 | 14.04 (11.53 to 16.55) | 13.21 (12.00 to 14.43) | 21.82 (15.30 to 28.34) | 15.46 (13.39 to 17.54) | <.001 |
| CD19 count, /μL | 80-616 | 210 (169.4 to 250.5) | 197.1 (163.0 to 231.2) | 178.2 (120.0 to 236.4) | 129 (108.4 to 149.6) | .004 |
| CD16+56 (%) | 5-26 | 17.66 (3.458 to 31.86) | 13.09 (11.22 to 14.97) | 8.92 (6.227 to 11.61) | 23.85 (20.21 to 27.49) | <.001 |
| CD16+56 count, /μL | 84-724 | 161.3 (82.20 to 240.3) | 183.5 (150.4 to 216.5) | 82.78 (55.13 to 110.4) | 190 (154.7 to 225.3) | .04 |
| IgG, g/L | 8-16 | 11.83 (10.32 to 13.34) | 11.81 (11.01 to 12.62) | 18.08 (15.44 to 20.73) | 13.79 (12.64 to 14.93) | <.001 |
| IgM, g/L | 0.4-3.45 | 1.19 (1.03 to 1.35) | 1.2 (1.07 to 1.33) | 1.08 (0.74 to 1.41) | 1.13 (1.0 to 1.27) | .79 |
| IgA, g/L | 0.76-3.9 | 1.9 (1.55 to 2.25) | 4.49 (–0.42 to 9.39) | 1.83 (1.44 to 2.22) |
2.23 (1.94 to 2.52) |
.71 |
| IgE, IU/mL | <100 | 71.7 (27.92 to 115.5) | 88.89 (41.23 to 136.6) | 59.83 (8.444 to 111.2) | 84.1 (54.48 to 113.7) | .89 |
| Complement C3, g/L | 0.81-1.6 | 0.78 (0.72 to 0.84) | 0.83 (0.79 to 0.87) | 0.89 (0.81 to 0.98) | 0.88 (0.82 to 0.94) | .09 |
| Complement C4, g/L | 0.1-0.4 | 0.2 (0.17 to 0.23) | 0.24 (0.22 to 0.27) | 0.22 (0.19 to 0.25) | 0.28 (0.25 to 0.31) | .003 |