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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Mar 11;59(19):7377–7383. doi: 10.1002/anie.201915493

Figure 3:

Figure 3:

On-DNA sulfonamide and reverse sulfonamide synthesis: (A) on-DNA sulfonamide reaction conditions and reaction scope. a aryl sulfonamide formation, aryl sulfinate (500 mM), iodine (500 mM), in EtOH, 18 h. b alkyl sulfonamide formation: alkyl sulfinate (1000 mM), NCS (500 mM), in EtOH, 1.5 h sonication. (B) reverse sulfonamide formation reaction conditions and reaction scope. c reaction conditions: rongalite (750 mM), DMSO, 18 h. wash with DMSO. amine (500 mM), DCDMH (500 mM), DMSO, 18 hr. (C) proposed RASS enabled workflow for performing multiple encoded diversification steps using a sensitive intermediate.