Table 4.

Univariate models for individuals with ADTKD-UMOD

Parameter	Observations (n)	Events	Reference category	Hazard ratio	C-statistic	P value
Gender	675	342	Male	1.78	0.556	0.00028
rs4293393 minor variant in phase with mUMOD	668	337	A (major)	0.6885	0.507	0.36
rs4293393 minor variant in phase with wtUMOD	494	221	A (major)	0.6152	0.529	0.064
rs4293393 variant (at least 1 G allele present)	499	224	2 A alleles present	0.6943	0.528	0.13
mUMOD type	675	342	p.(H177_R185del)		0.561
Cysteine gain				0.9234		0.88
Cysteine loss				0.9995		1.0
Deletion/insertion				0.6369		0.3
Hydrophobic amino acid gain				0.3197		0.066
Proline gain				0.5321		0.13
Other				0.6155		0.15
In vitro score	393	198		1.5457	0.591	0.0022
Cysteine-rich domains	675	342	All other domains	0.8247	0.521	0.38

ADTKD-UMOD, autosomal dominant tubulo-interstitial kidney disease due to UMOD mutations; mUMOD, mutant uromodulin; wtUMOD, wild-type uromodulin.

Data combine Wake Forest and International cohorts.