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. Author manuscript; available in PMC: 2021 Sep 10.
Published in final edited form as: J Med Chem. 2020 Aug 21;63(17):9977–9989. doi: 10.1021/acs.jmedchem.0c01111

Figure 2.

Figure 2.

Effects of compounds 9–13 on reducing the PRMT5 protein level in MCF-7 cells. MCF-7 cells were treated with compounds 9–13 at the indicated concentrations (0.2, 1, and 5 μM) for 6 d. Cell lysates were collected, and the PRMT5 protein levels were detected by western blots. The results are representative of at least two independent experiments.