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Effects of compounds 15, 17, and 21 on inhibiting the PRMT5 methyltransferase activity in a radioactive biochemical assay. Substrate: H4 (1–15)-biotin (400 nM). Cofactor: 3H-SAM (1 μM). EPZ015666 was used as a positive control. IC50 determination experiments were performed in duplicate, and the values are presented as mean ± SD.
