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Global proteomic analysis indicates that compound 15 is a highly selective PRMT5 degrader. MCF-7 cells were treated with compound 15 at 5 μM or DMSO for 5 d and then harvested and lysed for liquid chromatography–MS (LC–MS) analysis. LFQ was used to calculate the peptide intensity; the relative abundance of PRMT5 (LFQ intensity value) between the compound 15-treated and DMSO-treated groups is shown.
