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. Author manuscript; available in PMC: 2020 Nov 12.
Published in final edited form as: Nature. 2020 May 12;585(7824):268–272. doi: 10.1038/s41586-020-2324-7

Extended Data Figure 8. Viral loads in tissues collected from rhesus macaques infected with SARS-CoV-2.

Extended Data Figure 8.

Eight adult rhesus macaques were inoculated with SARS-CoV-2 isolate nCoV-WA1–2020 and euthanized on 3 (n=4) and 21 (n=4) dpi. Thirty-seven tissues were collected at necropsy and analyzed for the presence of viral RNA by qRT-PCR. Tissues are grouped by lung lobes collected on 3 dpi (a), with red symbols indicating tissues from which virus could be isolated in Vero E6 cells; other tissues from the respiratory tract on 3dpi (b); lymphoid tissues on 3 dpi (c); gastrointestinal tissueson 3 dpi (d); the central nervous system on 3 dpi (e); remaining tissues on 3 dpi (f); and all tissues collected on 21 dpi (g). Blue symbols in b-g indicate that viral mRNA was also detected in these tissues. Identical symbols have been used to denote identical animals throughout the figures in this manuscript. LN: lymph node; RUL: right upper lung lobe; RML: right middle lung lobe; RLL: right lower lung lobe; LUL: left upper lung lobe; LML: left middle lung lobe; LLL: left lower lung lobe; R: right; L: left.