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. Author manuscript; available in PMC: 2020 Nov 12.
Published in final edited form as: Nature. 2020 May 12;585(7824):268–272. doi: 10.1038/s41586-020-2324-7

Extended Data Figure 5. Histological changes in the respiratory tract of rhesus macaques infected with SARS-CoV-2.

Extended Data Figure 5.

(a) Squamous metaplasia of nasal turbinate respiratory epithelium (arrow). Magnification 400x. (b) SARS-CoV-2 antigen is detected by immunohistochemistry in respiratory epithelium of the nasal turbinate. Magnification 400x. (c) Essentially normal tonsil. Magnification 400x. (d) SARS-CoV-2 antigen is detected by immunohistochemistry in tonsillar macrophages. Magnification 400x. (e) Squamous metaplasia of tracheal columnar epithelium (arrow). Magnification 400x. (f) SARS-CoV-2 antigen is detected by immunohistochemistry in tracheal columnar epithelium. Magnification 400x. Tissue sections were collected from the same anatomical location for each animal (n=4) and organ; one tissue section was evaluated of the nasal turbinates of each animal; three tissue sections were evaluated from tonsil and trachea.