Extended Data Table 1.
Clinical signs observed in rhesus macaques inoculated with SARS-CoV-2.
| Animal | Clinical signs observed 1–6 dpi | Clinical signs observed 7–21 dpi | Observations at necropsy* |
|---|---|---|---|
| RM1 | Hunched posture; piloerection; tachypnea; flushed appearance; red eyes; very agitated; reduced appetite; mildly dehydrated. Euthanized 3 dpi. |
N/A | Gross lung lesions. Enlarged tonsils and mediastinal lymph nodes. Fluid-filled stomach, small and large intestine. |
| RM2 | Piloerection; dyspnea; reduced appetite. Euthanized 3 dpi. |
N/A | Fluid-filled stomach, small and large intestine. |
| RM3 | Piloerection; tachypnea; flushed appearance; reduced appetite; mildly dehydrated. Euthanized 3 dpi. |
N/A | Epistaxis. Gross lung lesions. Enlarged mediastinal lymph nodes. Fluid-filled stomach, small and large intestine. |
| RM4 | Hunched posture; piloerection; tachypnea; dyspnea; reduced appetite. Euthanized 3 dpi. |
N/A | Gross lung lesions. Foamy exudate from trachea. Enlarged mediastinal lymph nodes. Fluid-filled stomach, small and large intestine. |
| RM5 | Hunched posture; piloerection; tachypnea; dyspnea; reduced appetite. | Tachypnea; dyspnea; reduced appetite; mildly dehydrated. Recovered on 9 dpi. |
Gross lung lesions. Enlarged mesenteric lymph nodes. |
| RM6 | Hunched posture; piloerection; tachypnea; dyspnea; reduced appetite; serous nasal discharge. | Piloerection; bradypnea; mildly dehydrated; crusty nasal discharge. Recovered on 10 dpi. |
None. |
| RM7 | Hunched posture; piloerection; pale appearance; tachypnea; dyspnea; irregular; labored respirations; anorexia; mildly dehydrated; serous nasal discharge. | Hunched posture; piloerection; pale appearance; tachypnea; dyspnea; reduced appetite; mildly dehydrated; crusty nasal discharge. Recovered on 17 dpi. |
None. |
| RM8 | Hunched posture; piloerection; pale appearance; increased, dyspnea; reduced appetite; serous nasal discharge. | Hunched posture; piloerection; pale appearance; increased, dyspnea; nasal discharge; reduced appetite; mildly dehydrated; serous nasal discharge. Recovered on 13 dpi. |
Gross lung lesions. |
*
Incidental observations not related to coronavirus infection were omitted from this table.