Figure 5.
Safety assessment of Auroshell nanoparticles, an example for inorganic biomedical nanomaterials. (A) Scheme of the silica/gold core-shell structure of Auroshell nanoparticle. (B) Preclinical International Organization for Standardization (ISO) toxicological testing performed for Auroshell particles. (C) Mass balance data of mice receiving a single injection of Auroshell particles and sacrificed at the time points indicated. Gold content was detected by Neutron activation analysis (NAA). Reproduced with permission.[154] Copyright 2012, SAGE Publishing.