Skip to main content
. Author manuscript; available in PMC: 2021 Sep 9.
Published in final edited form as: Cell Host Microbe. 2020 Jun 10;28(3):411–421.e6. doi: 10.1016/j.chom.2020.05.015

Figure 5. The hsmRA operon decreases sensitivity to vancomycin in the presence of heme during infection.

Figure 5.

(A, B) Growth of WT, hsmR::CT and hsmA::CT in the presence or absence of vancomycin (100 μg/mL) and heme (10 μM). The data are a representative from three independent experiments with standard error of the mean. (C, D) CFU analysis of mice coinfected with WT and hsmR::CT or WT and hsmA::CT strains for 12 days post infection (DPI) with standard error of the mean (n=14/group). Vancomycin treatment (0.4 mg/mL) was administered on days 5–10 (denoted by gray shading) and removed on day 11. The data are presented with standard error of the mean. Statistical significance was determined using the multiple comparison two-way ANOVA test with the Bonferroni correction for multiple comparisons comparing the means of each group to one another. * denotes p-value < 0.05. See also Figure S4 and S5.