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. 2020 Sep 9;28(3):434–444.e4. doi: 10.1016/j.chom.2020.06.003

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Amino-Acid Variation in Residue 38 of H1 HA Determines Reactivity to Clonotype A but not Clonotype B

(A) Interaction of 54-4H03 with HA2 L38 in CA09 HA is shown. HA2 L38 is shown in stick representation and 54-4H03 in a surface electrostatic representation.

(B and C) (B) Binding curves of early intermediate and 54-1G05 from clonotype B, and (C) early intermediate, 54-4H03, 54-1G07 from clonotype A to CA09, NC99, and CA09 L38Q mutant HAs as measured by meso scale discovery (MSD). Antibodies were in IgG format.