Skip to main content
. 2020 Sep 9;28(3):434–444.e4. doi: 10.1016/j.chom.2020.06.003

Figure 5.

Figure 5

DH3–3-Encoded Phe of Clonotypes A and B Target Different Regions of the HA Stem

(A) The DH gene regions of MEDI8852, 56.a.09, 54-1G05 (clonotype B), and 54-4H03 (clonotype A) are aligned to the D3-3∗01 germline gene. For each antibody, the amino-acid sequence is shown below the nucleotide sequence. The amino-acid sequence from the frame 3 translation is shown for the D3-3∗01 germline gene. The Phe of interest is highlighted in red. Nucleotides from N-region additions are shown in lower case.

(B–E) CDR H3 loops of (B) MEDI8852, (C) 56.a.09, (D) 54-1G05, and (E) 54-4H03 are shown. The side chain of DH3-3-encoded Phe is shown in stick representation. HA is shown as a semi-transparent surface with superimposed tube representation for the backbone and Phe side chain of interest in stick representation. The N- and C-termini of the CDR H3 loops are indicated as “N” and “C,” respectively. For each antibody, the Kabat sequence number of the Phe of interest is indicated in parentheses.