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. 2020 Sep 9;28(3):434–444.e4. doi: 10.1016/j.chom.2020.06.003

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of Somatic Mutations in Clonotype B

(A) Sequence alignment of the heavy and light chains of representative antibodies from clonotype B are shown. Residues of interest are highlighted in red with their positions indicated. EI: early intermediate.

(B) Residues of interest are shown on the structure. The HA surface is colored in gray, and Fab light chain in cyan. The side chains of residues of interest are shown in stick representation.

(C) Binding curves of the early intermediate of clonotype B, 54-1G05, and different 54-1G05 mutants to H5 and H7 HAs as measured by meso scale discovery (MSD). Antibodies were in IgG format.