Extended Data Table 1.

Clinical and pathological observations in rhesus macaques inoculated with SARS-CoV-2 and treated with remdesivir.

Treatment	Animal	Clinical observations	Observations at necropsy
Remdesivir	RM1	Slightly decreased appetite	Mediastinal lymph nodes enlarged
	RM2	Slightly decreased appetite	None
	RM3	Slightly decreased appetite, pale appearance	Mediastinal lymph nodes enlarged
	RM4	Slightly decreased appetite, slightly dehydrated	Mediastinal lymph nodes enlarged
	RM5	Slightly decreased appetite	Mediastinal lymph nodes enlarged
	RM6	Mild dyspnea, pale appearance	Gross lung lesions; mediastinal lymph nodes enlarged
Vehicle solution	RM7	Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite	Gross lung lesions; mediastinal lymph nodes enlarged; focal hemorrhage in colon
	RM8	Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite	Gross lung lesions; mediastinal lymph nodes enlarged
	RM9	Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite	Gross lung lesions; mediastinal lymph nodes enlarged
	RM10	Tachypnea, dyspnea, pale appearance, slightly dehydrated	Gross lung lesions; mediastinal lymph nodes enlarged
	RM11	Piloerection, tachypnea, dyspnea, decreased appetite, pale appearance	Gross lung lesions; mediastinal lymph nodes enlarged
	RM12	Piloerection, tachypnea, dyspnea, decreased appetite	Gross lung lesions; mediastinal lymph nodes enlarged; ~5ml fluid in peritoneum