Extended Data Table 1.
Clinical and pathological observations in rhesus macaques inoculated with SARS-CoV-2 and treated with remdesivir.
Treatment | Animal | Clinical observations | Observations at necropsy |
---|---|---|---|
Remdesivir | RM1 | Slightly decreased appetite | Mediastinal lymph nodes enlarged |
RM2 | Slightly decreased appetite | None | |
RM3 | Slightly decreased appetite, pale appearance | Mediastinal lymph nodes enlarged | |
RM4 | Slightly decreased appetite, slightly dehydrated | Mediastinal lymph nodes enlarged | |
RM5 | Slightly decreased appetite | Mediastinal lymph nodes enlarged | |
RM6 | Mild dyspnea, pale appearance | Gross lung lesions; mediastinal lymph nodes enlarged | |
Vehicle solution | RM7 | Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite | Gross lung lesions; mediastinal lymph nodes enlarged; focal hemorrhage in colon |
RM8 | Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite | Gross lung lesions; mediastinal lymph nodes enlarged | |
RM9 | Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite | Gross lung lesions; mediastinal lymph nodes enlarged | |
RM10 | Tachypnea, dyspnea, pale appearance, slightly dehydrated | Gross lung lesions; mediastinal lymph nodes enlarged | |
RM11 | Piloerection, tachypnea, dyspnea, decreased appetite, pale appearance | Gross lung lesions; mediastinal lymph nodes enlarged | |
RM12 | Piloerection, tachypnea, dyspnea, decreased appetite | Gross lung lesions; mediastinal lymph nodes enlarged; ~5ml fluid in peritoneum |