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. Author manuscript; available in PMC: 2020 Dec 9.
Published in final edited form as: Nature. 2020 Jun 9;585(7824):273–276. doi: 10.1038/s41586-020-2423-5

Extended Data Table 1.

Clinical and pathological observations in rhesus macaques inoculated with SARS-CoV-2 and treated with remdesivir.

Treatment Animal Clinical observations Observations at necropsy
Remdesivir RM1 Slightly decreased appetite Mediastinal lymph nodes enlarged
RM2 Slightly decreased appetite None
RM3 Slightly decreased appetite, pale appearance Mediastinal lymph nodes enlarged
RM4 Slightly decreased appetite, slightly dehydrated Mediastinal lymph nodes enlarged
RM5 Slightly decreased appetite Mediastinal lymph nodes enlarged
RM6 Mild dyspnea, pale appearance Gross lung lesions; mediastinal lymph nodes enlarged
Vehicle solution RM7 Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite Gross lung lesions; mediastinal lymph nodes enlarged; focal hemorrhage in colon
RM8 Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite Gross lung lesions; mediastinal lymph nodes enlarged
RM9 Piloerection, hunched posture, tachypnea, dyspnea, decreased appetite Gross lung lesions; mediastinal lymph nodes enlarged
RM10 Tachypnea, dyspnea, pale appearance, slightly dehydrated Gross lung lesions; mediastinal lymph nodes enlarged
RM11 Piloerection, tachypnea, dyspnea, decreased appetite, pale appearance Gross lung lesions; mediastinal lymph nodes enlarged
RM12 Piloerection, tachypnea, dyspnea, decreased appetite Gross lung lesions; mediastinal lymph nodes enlarged; ~5ml fluid in peritoneum