Table 2. Transplant Characteristics.
ICIs=Immune Checkpoint Inhibitors, NA=not applicable. IQR=interquartile range
| All patients | ICIs | No-ICIs | P value | |
|---|---|---|---|---|
|
Donor type no. (%) HLA haploidentical |
89 (85%) | 26 (70%) | 63 (93%) | 0.009 |
| HLA matched related | 5 (5%) | 3 (8%) | 2 (3%) | |
| HLA matched unrelated | 11 (10%) | 8 (22%) | 3 (4%) | |
| Median donor age (IQR in years) | 37 (IQR: 25, 52) |
27 (IQR: 22, 41) |
41 (IQR: 27, 54) |
0.008 |
|
Allograft source no. (%) Bone marrow |
94 (90%) | 31 (84%) | 63 (93%) | 0.4 |
| Peripheral Blood | 9 (9%) | 5 (14%) | 4 (6%) | |
| Cord blood | 2 (2%) | 1 (3%) | 1 (1%) | |
|
Sex mismatch no. (%) Matched |
59 (62%) | 19 (63%) | 40 (62%) | 0.9 |
| Female donor to male recipient | 18 (19%) | 6 (20%) | 12 (18%) | |
| Male donor to female recipient | 18 (19%) | 5 (17%) | 13 (20%) | |
| Major ABO mismatch no. (%) | 9 (9%) | 6 (17%) | 3 (4%) | 0.03 |
| CMV reactivation no. (%) | 36 (34%) | 9 (24%) | 27 (40%) | 0.1 |
|
Count recovery time median (range) in days Days to neutrophil count recovery |
16 (4, 751) | 16 (12, 751) | 16 (4, 64) | 0.3 |
| Days to platelet count recovery | 24 (11, 112) | 24 (11, 112) | 24 (11, 76) | 0.9 |
|
Engraftment/Chimerism at day +60 Full donor chimerism (<5% patient) |
78 (74.2%) | 22 (59.4%) | 56 (82.3%) | 0.04 |
| Mixed chimerism (5–94% patient) | 17 (16.1%) | 9 (24.3%) | 8 (11.7%) | |
| Graft Failure | 10 (9.5%) | 6 (16.2%) | 4 (5.8%) |